Abstract
A large number of drugs have side-effects involving the gastrointestinal tract. An
increasing number of drugs are becoming available over-the-counter, empowering patients
to treat themselves without prescription. Therefore it is vital that patients (and
doctors) are made aware of the possible side-effects and unwanted complication due
to the combination of different pharmaceutical ingredients. This review focuses on
the possible gastrointestinal side-effects of frequently used and clinically important
drugs.
Zusammenfassung
Eine große Zahl von Medikamenten verursacht gastrointestinale Nebenwirkungen. Die
Zunahme von nicht verschreibungspflichtigen Wirkstoffen und ihre teilweise unkritische
Einnahme unterstreicht die Wichtigkeit der Kenntnis der Nebenwirkungen. Der vorliegende
Übersichtsartikel stellt die wichtigsten Nebenwirkungen häufiger und z. T. frei verkäuflicher
Arzneimittel auf den Gastrointestinaltrakt zusammen.
Literatur
- 1
Strauss W L, Ofman J J.
Gastrointestinal toxicity associated with nonsteroidal anti-inflammatory drugs Epidemiologic
and economic issues.
Gastroenterol Clin North Am.
2001;
30
895-920
- 2
Stiel D.
Exploring the link between gastrointestinal complications and over-the-couter analgesics:
current issues and considerations.
Am J Ther.
2000;
7
91-8
- 3 Bettendorf U, Gebbers J O, Möller P, Morgenroth K, Otto H F, Remmele W. Verdauungstrakt. Pathologie
1996
- 4 Fülgraff G, Palm D. Pharmakotherapie. Klinische Pharmakologie 1986
- 5
Blackshaw A J, Levison D A.
Eosinophilic infiltrates of the gastrointestinal tract.
J Clin Pathol.
1986;
39
1-7
- 6
Fendrick A M, Scheiman J M.
Helicobacter pylori and NSAID gastropathy: an ambiguous association.
Curr Rheumatol Rep.
2001;
3
107-11
- 7
Schnitzer T J.
Cyclooxygenase-2-specific inhibitors: are they safe?.
Am J Med.
2001;
110
6-49
- 8
Cronstein B N.
Cyclooxygenase-2- selective inhibitors: translating pharmacology into clinical utility.
Cleve Clin J Med.
2002;
69
13-9
- 9
Conklin K A.
Dietary antioxidants during cancer chemotherapy: impact on chemotherapeutic effectiveness
and development of side effects.
Nutr Cancer.
2000;
37
1-18
- 10
Campbell D A, Piercey J RA, Shnitka T K. et al .
Cytomegalovirus-associated gastric ulcer.
Gastroenterology.
1977;
72
533-535
- 11
Dieterich D T.
Cytomegalovirus: a new gastrointestinal pathogen in immunocompromised patients.
Am J Gastroenterol.
1987;
82
764-765
Prof. Dr. med. Andrea Tannapfel
Institut für Pathologie · Universitätsklinikum Leipzig
Liebigstraße 26
04103 Leipzig
Phone: 03 41/9 71 50-36
Fax: 03 41/9 71 50-69
